Chou, Stella T;
Alsawas, Mouaz;
Fasano, Ross M;
Field, Joshua J;
Hendrickson, Jeanne E;
Howard, Jo;
Kameka, Michelle;
Kwiatkowski, Janet L;
Pirenne, France;
Shi, Patricia A;
Stowell, Sean R;
Thein, Swee Lay;
Westhoff, Connie M;
Wong, Trisha E;
Akl, Elie A.
Red cell transfusions remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. Guidance for specific indications and administration of transfusion, as well as screening, prevention, and management of alloimmunization, delayed hemolytic transfusio...
BACKGROUND
Red blood cell (RBC) transfusions remain essential in the treatment of patients with sickle cell disease (SCD) and β‐thalassemia. Alloimmunization, a well‐documented complication of transfusion, increases the risk of delayed hemolytic transfusion reactions, complicates crossmatching and i...
Anemia, Sickle Cell,
Erythrocyte Transfusion/22074,
Hemoglobinopathies/therapy,
Transfusion Reaction/prevention & control,
Transfusion Reaction,
beta-Thalassemia/therapy,
Anemia, Sickle Cell/therapy,
Erythrocytes/metabolism,
Anemia, Sickle Cell/drug therapy,
Erythrocyte Transfusion,
Isoantibodies/therapeutic use,
Isoantigens/therapeutic use
GRADE was used to evaluate 13-valent Pneumococcal Conjugate Vaccine (PCV13) for routine use among immunocompromised children aged 6 through 18 years.
Evidence of benefits, harms, values and preferences, and cost-effectiveness were reviewed in accordance with GRADE methods.[1] The primary policy question...
This guideline covers managing acute painful sickle cell episodes in children, young people and adults who present at hospital, from presentation until when they are discharged. It aims to reduce variation in how acute episodes are managed in hospital, focusing on effective, prompt and safe pain relief.
...
Anemia, Sickle Cell/drug therapy,
Acute Pain/drug therapy,
Outpatient Clinics, Hospital,
Analgesics, Opioid/therapeutic use,
Analgesia,
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use,
Pain Management
